Synthesis and Cyclization of Modified Prostate-specific Antigen Activating Peptides via Solid-phase Peptide Synthesis Method Joel Ekabe (235142) Supervisor: Ale Närvänen Co-supervisors: Miikka Pakkala & Janne Weisell
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Novel and efficient method for solid phase synthesis of urea-containing peptides targeting prostate specific membrane antigen (PSMA) in comparison with current methods
The basic chemical structure of most prostate specific membrane antigen (PSMA) inhibitors which are now in pre-clinical and clinical studies is Glu-Ureido-based peptides. Synthesis of urea-based PSMA inhibitors includes two steps: 1- isocyanate intermediate formation and 2- urea bond formation. In current methods, isocyanate is formed in liquid phase and then reacts with amine existing in liqui...
متن کاملNovel and efficient method for solid phase synthesis of urea-containing peptides targeting prostate specific membrane antigen (PSMA) in comparison with current methods
The basic chemical structure of most prostate specific membrane antigen (PSMA) inhibitors which are now in pre-clinical and clinical studies is Glu-Ureido-based peptides. Synthesis of urea-based PSMA inhibitors includes two steps: 1- isocyanate intermediate formation and 2- urea bond formation. In current methods, isocyanate is formed in liquid phase and then reacts with amine existing in liqui...
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1 Chemistry 2 Liquid-phase synthesis 3 Solid-phase synthesis 3.1 Boc SPPS 3.2 Fmoc SPPS 3.3 BOP SPPS 4 Solid supports 4.1 Polystyrene resin 4.2 Polyamide resin 5 Protecting groups 5.1 Fmoc protective group 5.2 Boc protective group 5.3 Benzyloxy-carbonyl (Z) group 5.4 Alloc protecting group 5.5 Lithographic protecting groups 6 Activating groups 6.1 Carbodiimides 6.2 Aromatic oximes 7 Synthesizin...
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